Physiolibrary.Organs.Heart.Components

Package Content

Name	Description
Ventricle
SA_Node
ANP
BaroReceptors
Diastole
Systole
VentricleVolumeAndPumping	Multiple PressureFlow connector with pressures from multiple inputs
Metabolism
Tissue	Heart tissue

Physiolibrary.Organs.Heart.Components.Ventricle

Information

Heart ventricle.

like
QHP 2008 / VascularCompartments/LeftVentricle/*



The pressure-volume characteristics of both ventricles in diastole
and systole will be described using a power function.

  P = A * (V ^ n)

P = Pressure
V = Volume
A = Scale Factor
n = curvature

The function is invertable.

  V = (P/A) ^ (1/n)

Some typical values

                                 Right                 Left
                           ---------------------- ------------------------
Nominal Vol                     87.5                  87.5
Nominal TMP                      3.0                   6.0
Compliance                      29.2                  14.6
Pericardial P                   -3.0                  -3.0

DIASTOLE
  EDP                            1.0                   5.0
  EDV                          125.0                 125.0
  TMP                            4.0                   8.0
  n                              2.0                   2.0
  V^n                        15625.0               15625.0
  A                              0.00026               0.00051

SYSTOLE
  ESP                           22.0                 120.0
  ESV                           50.0                  50.0
  TMP                           25.0                 123.0
  n                              0.5                   0.5
  V^n                            7.07                  7.07
  A                              3.53                 17.39

Extends from Physiolibrary.Fluid.Interfaces.CompositionSetup (Initial substances composition setup), Physiolibrary.Icons.HeartVentricle.

Parameters

Name	Description
replaceable package Medium	Medium model
stateName
AmbientPressure	Environment ambient pressure [Pa]
initialVol	Initial blood volume in ventricle [m3]
K	time adaptation coeficient of average ventricle blood volume [Hz]
BasicCompliance	[m3/Pa]
NormalExternalPressure	Typical value of pericardium cavity pressure (relative to environment ambient pressure) [Pa]
Initialization of medium composition
massFractions_start[:]	* Masses of all base molecules. If size is nS-1 then last value is 1-sum(others). If size is nS then all values are scaled to sum==1. [1]
extraConcentration_start[Medium.nC]	Extra substance amounts per kilogram of solution
Initialization
temperature_start	Initial temperature [K]
pressure_start	Initial pressure [Pa]
Diastole
NormalEndDiastolicVolume	Typical value of blood volume in ventricle after filling [m3]
NormalFillingPressure	Typical value of filling pressure relative to pericardium pressure [Pa]
stiffnes	Relative stiffnes (1 if normal) [1]
n_Diastole	Exponent of P-V characteristic of EDV curve on filling pressure [1]
Systole
NormalSystolicPressure	Typical value of systolic pressure relative to pericardium pressure [Pa]
NormalEndSystolicVolume	Typical value of blood volume in ventricle after ejection [m3]
additionalPressure_Systolic	Pressure difference between mean and systolic pressure [Pa]
contractilityBasic	Relative contractility (1 if normal) [1]
n_Systole	Exponent of P-V characteristic of ESV curve on systolic pressure [1]

Connectors

Name	Description
replaceable package Medium	Medium model
port_a
port_b
MotionPower	[W]
HeartRate	[Hz]
GangliaGeneral	Sympathicus neural activity from general ganglia [Hz]
Pericardium	pericardium pressure [Pa]

Physiolibrary.Organs.Heart.Components.SA_Node

Information

Extends from Physiolibrary.Icons.SinoatrialNode.

Parameters

Name	Description
BaseHeartRate	[Hz]
SympatheticEffect[:, 3]
ParasympatheticEffect[:, 3]

Connectors

Name	Description
BetaReceptorsEffect
Rate	[Hz]
VagusNerve_NA_Hz	[Hz]

Physiolibrary.Organs.Heart.Components.ANP

Information

Extends from Physiolibrary.Icons.Heart.

Connectors

Name	Description
busConnector
ANP
NephronANP_Log10Conc

Physiolibrary.Organs.Heart.Components.BaroReceptors

Information

Extends from Physiolibrary.Icons.Barroreceptor.

Parameters

Name	Description
AdaptivePressure	[Pa]
Tau	[s]
PressureChangeOnNA[3, :]

Connectors

Name	Description
rightAtriumPressure	[Pa]
NA	[1]
leftAtriumPressure	[Pa]
pericardiumPressure	[Pa]

Physiolibrary.Organs.Heart.Components.Diastole

Information

Extends from Physiolibrary.Fluid.Interfaces.PartialAbsoluteSensor (Partial component to model a sensor that measures a potential variable).

Parameters

Name	Description
replaceable package Medium	Medium in the sensor
stiffnes	parametrization of end diastolic volume curve [1]
n_Diastole	parametrization of end systolic volume curve [1]
NormalFillingPressure	Typicall value of mean arterial filling pressure (relative to environment ambient pressure) [Pa]
NormalExternalPressure	Typical value of pericardium cavity pressure (relative to environment ambient pressure) [Pa]
NormalEndDiastolicVolume	= (NormalDiastolicPressure/Abasic_Diastole)^n_Diastole [m3]
AmbientPressure	Environment ambient pressure [Pa]

Connectors

Name	Description
port
externalPressure	pericardium pressure around ventricle [Pa]
EDV	[m3]

Physiolibrary.Organs.Heart.Components.Systole

Information

Extends from Physiolibrary.Fluid.Interfaces.PartialAbsoluteSensor (Partial component to model a sensor that measures a potential variable).

Parameters

Name	Description
replaceable package Medium	Medium in the sensor
n_Systole	parametrization of end diastolic volume curve [1]
NormalSystolicPressure	Typical value of mean arterial pressure (relative to environment ambient pressure) [Pa]
NormalExternalPressure	Typical value of pericardium cavity pressure (relative to environment ambient pressure) [Pa]
NormalEndSystolicVolume	= 2.64 ml for left ventricle, parametrization of end systolic volume curve [m3]
additionalPressure_Systolic	parametrization of end systolic volume curve [Pa]
AmbientPressure	Environment ambient pressure [Pa]

Connectors

Name	Description
port
contractility	heart muscle contractility [1]
ESV	[m3]
externalPressure	pressure around ventricle [Pa]

Physiolibrary.Organs.Heart.Components.VentricleVolumeAndPumping

Multiple PressureFlow connector with pressures from multiple inputs

Information

Model has a vector of continuous Real input signals as pressures for vector of pressure-flow connectors.

Extends from Physiolibrary.Icons.Pump, Physiolibrary.Fluid.Interfaces.CompositionSetup (Initial substances composition setup).

Parameters

Name	Description
replaceable package Medium	Medium model
K	[Hz]
stateName
Initialization of medium composition
massFractions_start[:]	* Masses of all base molecules. If size is nS-1 then last value is 1-sum(others). If size is nS then all values are scaled to sum==1. [1]
extraConcentration_start[Medium.nC]	Extra substance amounts per kilogram of solution
Initialization
temperature_start	Initial temperature [K]
pressure_start	Initial pressure [Pa]

Connectors

Name	Description
BloodFlow	heart cardiac output [m3/s]
VentricleSteadyStateVolume	heart ventricle steady state volume [m3]
Volume	[m3]
replaceable package Medium	Medium model
port_a	Inflow
port_b	Outflow
port_c	Measurement port

Physiolibrary.Organs.Heart.Components.Metabolism

Information

Extends from Icons.Heart, Icons.MetabolismPart.

Parameters

Name	Description
replaceable package Blood	Blood medium model
StructureEffect	Structure effect on metabolism (1..OK, 0..zero basal functions) [1]
BasalPowerPerKg	Rate of energy consumption by basal metabolism in 1 kg of tissue [W/kg]
TissueSize	Tissue mass [kg]
MotionEffeciency	Motion effeciency without basal metabolism [1]

Connectors

Name	Description
replaceable package Blood	Blood medium model
y
a_port
b_port
motionPower	Power needed for motion [W]

Physiolibrary.Organs.Heart.Components.Tissue

Heart tissue

Information

Extends from Physiolibrary.Icons.PerfusionDO, Physiolibrary.Icons.LeftHeart, Icons.MetabolismPart.

Parameters

Name	Description
replaceable package Blood
BasicLargeVeselsConductance	[m3/(Pa.s)]
BasicSmallVeselsConductance	[m3/(Pa.s)]
FunctionFailed	true if function failed
StructureEffect	Structure effect on metabolism (1..OK, 0..zero basal functions) [1]
BasalPowerPerKg	Rate of energy consumption by basal metabolism in 1 kg of tissue [W/kg]
TissueSize	Tissue mass [kg]
MotionEffeciency	Motion effeciency without basal metabolism [1]

Connectors

Name	Description
replaceable package Blood
motionPower	Total rate of motion energy (external work per time) [W]
port_a	Blood inflow
port_b	Blood outflow
Ganglia	Sympathetic ganglia general neural activity [Hz]

Automatically generated Wed Oct 11 14:54:26 2023.